COMPOUND

Compounds / Bioregulators

Prostamax

Prostamax / Prostagen (Lys-Glu-Asp-Pro / KEDP Tetrapeptide)

Bioregulators SubQ · Oral Not FDA approved

Khavinson family bioregulator developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Synthetic tetrapeptide marketed for prostate health and chronic prostatitis adjunct. Most efficacy data is from one Russian lab; independent Western replication is essentially absent. NOT approved for prostatitis or BPH treatment in any jurisdiction.

At a glance

Routes
SubQ · Oral
Vial sizes
20 mg
Evidence base
1 study 1 preclinical

Mechanism

Per the Khavinson 'short-peptide bioregulator' hypothesis, KEDP is proposed to bind condensed chromatin in aged or dysfunctional prostate cells, triggering decondensation of heterochromatin and re-opening silenced gene regions in nucleolar organizer regions. Mechanism is contested in mainstream pharmacology because tetrapeptides are normally degraded in serum within minutes. Reported preclinical effects: anti-inflammatory effect in chronic prostatitis animal models, suppression of lymphocytic infiltration, reduction of vascular congestion / fibrosis / stromal edema, restoration of acinar epithelial structure.

Dosing

No standardized human dosing has been established. Every catalogued study for Prostamax is preclinical or a literature review. Amounts used in animal models do not translate directly to humans.

Published evidence

  1. Animal in vivo 2013

    Effects of tetrapeptide KEDP on prostate inflammation in animal models of chronic prostatitis

    Khavinson VK, Lin'kova NS, et al. Bull Exp Biol Med

    KEDP reduced inflammatory markers and restored prostate epithelial structure in chronic prostatitis rat model.

Reported side effects

Long-term safety unverified outside Russia
Unknown Mild · Khavinson group reports a clean AE profile; no Western replication.

Interactions

  • Testagen Synergy

    Both target male reproductive axis (prostate + testes Khavinson stack).

Reconstitution and storage

20 mg vial; 2-5 mL BAC water. At 4 mg/mL, 100 mcg = 0.025 mL.

Lyophilized: room temp short-term, refrigerate for >30 days. Reconstituted: refrigerate, use within 30 days.

Open the reconstitution calculator for Prostamax