COMPOUND

Compounds / Bioregulators

Renelon

Renelon / Pielotax (Tyr-Glu-Asp-Trp / YEDW Tetrapeptide; renal bioregulator)

Bioregulators SubQ · Oral Not FDA approved

Khavinson family bioregulator developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Synthetic tetrapeptide marketed for kidney function support; frequently bundled with or confused for the polypeptide complex Pielotax (renal cytomax). Most efficacy data is from one Russian lab; independent Western replication is essentially absent. Sequence YEDW is plausible but not as cleanly confirmed across vendor sources as KE/KED/AEDR.

At a glance

Routes
SubQ · Oral
Vial sizes
20 mg
Evidence base
1 study 1 preclinical

Mechanism

Per the Khavinson 'short-peptide bioregulator' hypothesis, YEDW is proposed to bind DNA in renal nephron cells, upregulating differentiation and protein synthesis genes. Mechanism is contested in mainstream pharmacology because tetrapeptides are normally degraded in serum within minutes. Reported effects (limited literature): anti-inflammatory effect in cisplatin-induced acute renal failure model, reduction of protein excretion and electrolyte loss, normalization of diuresis and creatinine excretion, tissue regeneration markers in renal tubular cells.

Dosing

No standardized human dosing has been established. Every catalogued study for Renelon is preclinical or a literature review. Amounts used in animal models do not translate directly to humans.

Published evidence

  1. Animal in vivo 2015

    Peptides Restore Functional State of the Kidneys During Cisplatin-Induced Acute Renal Failure

    Khavinson VK, Lin'kova NS, et al. Bull Exp Biol Med

    Polypeptide complex from kidney + short peptides (AED, EDL, AEDG) reduced protein excretion and normalized diuresis in cisplatin-induced ARF rat model. Note: study covered the kidney peptide complex / related short peptides, not specifically YEDW.

    PMID 26515176

Reported side effects

Long-term safety unverified outside Russia
Unknown Mild · Khavinson group reports a clean AE profile; no Western replication. Caution in advanced CKD. PK in renal impairment untested.

Reconstitution and storage

20 mg vial; 2-5 mL BAC water. At 4 mg/mL, 100 mcg = 0.025 mL.

Lyophilized: room temp short-term, refrigerate for >30 days. Reconstituted: refrigerate, use within 30 days.

Open the reconstitution calculator for Renelon