COMPOUND

Compounds / Healing

BPC-157

Body Protection Compound-157

Healing SubQ · Oral Compoundable (FDA Cat. 1)

A synthetic 15-amino-acid peptide derived from a fragment of human gastric juice protein. The most widely used healing peptide in the biohacking community.

At a glance

Half-life
~30 min ~30 min (estimated from rat/dog PK data). No human PK studies published.
Routes
SubQ · Oral
Vial sizes
5 mg · 10 mg
Evidence base
5 studies 1 human · 1 review · 3 preclinical

Mechanism

Upregulates growth hormone receptor expression in fibroblasts, promotes angiogenesis via VEGF pathways, enhances nitric oxide signaling, suppresses pro-inflammatory cytokines (TNF-alpha, IL-6), stimulates fibroblast migration and collagen deposition. First published human IV safety data shows tolerability. Interacts with dopaminergic, serotonergic, and opioid systems.

Dosing

Any amounts shown here are reported from published studies only. 1 of 5 catalogued studies involved human subjects. COMPOUND does not publish its own dosing guidance.

Published evidence

  1. Human pilot 2025

    Safety of Intravenous Infusion of BPC157 in Humans: A Pilot Study

    Lee TC, Burgess AN Altern Ther Health Med

    First published human IV safety data. 2 healthy adults tolerated infusion with no adverse effects.

    PMID 40131143

  2. Review 2025

    Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review

    Vasireddi N, Hahamyan H, Salata MJ, et al. HSS J

    36 studies reviewed (35 preclinical, 1 clinical). Improved functional and structural outcomes in musculoskeletal injuries.

    DOI 10.1177/15563316251355551

  3. Animal in vivo 2011

    BPC 157 promotes tendon outgrowth, cell survival, and migration

    Chang CH, et al. J Applied Physiology

    BPC-157 enhances tendon fibroblast outgrowth and migration in vitro and in vivo.

    PMID 21030672

  4. Animal in vivo 1999

    The influence of a novel pentadecapeptide, BPC 157, on the healing of transected Achilles tendon in rats

    Sikiric P, Seiwerth S, Grabarevic Z, et al. J Appl Physiol

    Accelerated soft-tissue (tendon) healing versus controls in vivo

    PMID 10470706

  5. Animal in vivo 1993

    A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis

    Sikiric P, Petek M, Rucman R, et al. J Physiol Paris

    First characterization of BPC-157 as a stable gastric pentadecapeptide with organoprotective properties.

Reported side effects

Nausea
Occasional Mild · More common with oral route
Dizziness
Rare Mild
Injection site irritation
Occasional Mild

Interactions

  • TB-500 Synergy

    Complementary healing mechanisms: BPC-157 drives local repair via angiogenesis, TB-500 drives systemic repair via stem cell mobilization.

  • NSAIDs Synergy

    BPC-157 is gastroprotective and may counteract NSAID-induced GI damage.

Reconstitution and storage

Typical: 2mL BAC water per 5mg vial = 250mcg per 10 units on insulin syringe. Drip water slowly down side of vial. Do not shake.

Lyophilized: freezer (-20C). Reconstituted: refrigerate (2-8C), use within 28 days.

Open the reconstitution calculator for BPC-157