COMPOUND

Compounds / Healing

TB-500

Thymosin Beta-4 Fragment (amino acids 17-23)

Healing SubQ Compoundable (FDA Cat. 1)

Synthetic version of the active region of thymosin beta-4, a naturally occurring protein found in virtually all human cells. Works systemically for tissue repair.

At a glance

Half-life
~2 h ~2 hours plasma. Tissue residence time significantly longer; supports twice-weekly dosing.
Routes
SubQ
Vial sizes
5 mg · 10 mg
Evidence base
2 studies 1 review · 1 preclinical

Mechanism

Primary regulator of monomeric actin (G-actin) availability: sequesters 40-50% of the G-actin pool. Controls cytoskeletal reorganization for cell migration. Promotes angiogenesis, stem cell mobilization, inflammatory cytokine downregulation, and ECM remodeling.

Dosing

No standardized human dosing has been established. Every catalogued study for TB-500 is preclinical or a literature review. Amounts used in animal models do not translate directly to humans.

Published evidence

  1. Review 2012

    Thymosin beta 4: a multi-functional regenerative peptide

    Goldstein AL, Hannappel E, Sosne G, Kleinman HK Expert Opin Biol Ther

    Comprehensive review of TB4's regenerative role across wound healing, cardioprotection, and neuroprotection.

    PMID 22074294

  2. Animal in vivo 1999

    Thymosin beta4 accelerates wound healing

    Malinda KM, Sidhu GS, Mani H, et al. J Investigative Dermatology

    42% increased reepithelialization at day 4, 61% at day 7 vs controls.

    PMID 10469335

Reported side effects

Injection site irritation
Common Mild · Redness, swelling, tenderness. Self-resolving within 24 hours.
Fatigue/lethargy
Occasional Mild · Temporary
Headache
Occasional Mild
Cancer risk (theoretical)
Theoretical Serious · Pro-angiogenic properties could theoretically support tumor vascularization. Treated as contraindicated in active malignancy.

Interactions

  • BPC-157 Synergy

    The 'Wolverine Stack.' Complementary healing phases: TB-500 suppresses inflammation systemically, BPC-157 drives local repair.

Reconstitution and storage

Typical: 2mL BAC water per 5mg vial. Store refrigerated 2-8C. Use within 21-28 days.

Lyophilized: freezer. Reconstituted: refrigerate, use within 3-4 weeks.

Open the reconstitution calculator for TB-500