COMPOUND

Compounds / GH secretagogues

Ipamorelin

Ipamorelin (NNC 26-0161)

GH secretagogues SubQ Not FDA approved

The first selective GH secretagogue. Stimulates GH release WITHOUT significantly raising cortisol or prolactin. The cleanest GHRP available.

At a glance

Half-life
~2 h ~2 hours.
Routes
SubQ
Vial sizes
2 mg ยท 5 mg
Evidence base
1 study 1 preclinical

Mechanism

Selective GHS-R1a agonist on pituitary somatotrophs. Stimulates GH release and suppresses somatostatin. Unlike GHRP-2/GHRP-6, does not significantly raise cortisol, prolactin, or appetite; selectivity maintained even at 200x the GH-releasing ED50.

Dosing

No standardized human dosing has been established. Every catalogued study for Ipamorelin is preclinical or a literature review. Amounts used in animal models do not translate directly to humans.

Published evidence

  1. Animal in vivo 1998

    Ipamorelin, the first selective growth hormone secretagogue

    Raun K, Hansen BS, Johansen NL, et al. Eur J Endocrinol

    Ipamorelin selectively releases GH without elevating ACTH or cortisol, even at 200x the GH-releasing ED50.

Reported side effects

Headache
Occasional Mild
Lightheadedness
Occasional Mild

Interactions

  • CJC-1295 (no DAC) Synergy

    The gold standard GH stack. GHRH + GHRP synergy produces 3-10x greater GH pulse than either alone.

Reconstitution and storage

Typical: 2mL BAC water per 5mg vial = 250mcg per 10 units.

Lyophilized: freezer. Reconstituted: refrigerate, use within 4-6 weeks.

Open the reconstitution calculator for Ipamorelin